Neuropsychology and Brain Health Lab

實驗室簡介

本實驗室關注認知老化、失智風險因子與神經心理評估的跨領域研究，融合臨床與理論基礎，結合行為科學、神經心理學與公共健康觀點，目標為發展早期偵測工具與文化適用的臨床實務應用。

研究方向

• 認知退化的預測因子
• 語意記憶與神經網絡
• 台灣本土化心理測驗工具開發

實驗室成員

主持人： 張馨德 博士

研究助理： 林庭亘

碩士生： 莊曉彤、楊淳傅、徐健皓、覃馨樺、莊鎮華、葉湘文、馮旭卉、黃煦茗、吳竣珽

研究專題生： 紀采欣、連逸芸、張閎綸、葛周全

研究成果

期刊論文

Li, H.-Y., Lao, I.-H., Chen, Y.-C., Chang, H.-T., Chen, K.-T. (2025). Impact of subventricular zone invasion on preoperative cognitive decline in diffuse glioma patients. Neurosurgery. (accepted)(SCI)

Chang, H.-T., Hua, M.-S., Chiu, M.-J., (2025). Optimizing machine learning models for detecting cognitive and subjective cognitive complaint patterns among mild cognitive impairment patients. Chinese Journal of Psychology, vol.67, 77–100.(TSSCI)

Chiu, P.-Y., Yang, C.-C., Mahoor, M. H., Chang, H.-T.* (2024). Cognitive assessment in facilitating early detection of dementia. Frontiers in Dementia, 2, 1–2.

Cheng, S.-C., Hua, M.-S., Liao, Y.-C., Chang, H.-T.* (2024). Psychometric properties and norms of the Trail Making Test and the Color Trails Test among elderly individuals in Taiwan: A preliminary study, Chinese Journal of Psychology, vol.66, p.215-245.(TSSCI)

Chang, H.-T., Chan, P.-C, Chiu, P.-Y. (2024). Non-linear relationship between serum cholesterol levels and cognitive change among older people in the preclinical and prodromal stages of dementia: A retrospective longitudinal study in Taiwan, BMC Geriatrics , vol.24 , p.474-474.(SSCI)(SCI)

Lyu, W.-J., Chiu, P.-Y., Liu, C.-H., Liao, Y.-C., Chang, H.-T.* (2024). Determining optimal cutoff scores of Cognitive Abilities Screening Instrument to identify dementia and mild cognitive impairment in Taiwan , BMC Geriatrics, vol.24, p.216-216.(SSCI)(SCI)

Ku, Y.-T., Hua, M.-S., Chiu, P.-Y., Liao, Y.-C., Chang, H.-T.* (2024). Development of a revised version of Subjective Memory Complaints Questionnaire in Taiwan: A preliminary study, 2024 , Archives of Clinical Neuropsychology, vol.39, p.78-91.(SSCI)(SCI)

Chiu, H.-Y., Chang, H.-T., Chan, P.-C., Chiu, P.-Y. (2023). Cholesterol levels, hormone replacement therapy, and incident dementia among older adult women, Nutrients , vol.15 , p.4481-4481.(SCI)

Fan, S.-M, Chiu, P.-Y., Liu, C.-H., Liao, Y.-C., Chang, H.-T.* (2023). Predictive value of hypercholesterolemia, vegetarian diet, and hypertension for incident dementia among elderly Taiwanese individuals with low educational levels, Therapeutic Advances in Chronic Disease , vol.27 , p.20406223231171549-20406223231171549.(SCI)

Li, T.-C., Hua, M.-S., Liu, M.-Y., Liao, Y.-C., Chang, H.-T.* (2023). Extending normative data of the Paced Auditory Serial Addition Test to account for preliminary psychometric properties among elderly individuals in Taiwan, Archives of Clinical Neuropsychology, vol.38, p.264-269.(SSCI)(SCI)

Chang, H.-T., Chiu, P.-Y. (2023). Development of a simple screening tool for determining cognitive status in Alzheimer's disease, PLOS ONE , vol.18 , p.e0280178-e0280178.(SCI)

Huang, Y.-C., Liu, C.-H., Liao, Y.-C., Chang, H.-T.*, Chiu, P.-Y. (2022). Arrhythmia and other modifiable risk factors in incident dementia and MCI among elderly individuals with low educational levels in Taiwan, Frontiers in Aging Neuroscience, vol.14, p.992532-992532.(SCI)

Tzeng, R.-C., Yang, Y.-W., Hsu, K.-C., Chang, H.-T, Chiu, P.-Y. (2022). Sum of boxes of the Clinical Dementia Rating scale highly predict conversion or reversion in predementia stages, Frontiers in Aging Neuroscience , vol.14 , p.1021792-1021792.(SCI)

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Liu, M.-Y., Fan, W.-C., Cheng, T.-W., Lai, Y.-M., Hua, M.-S. (2022). Deterioration and predictive values of semantic networks in mild cognitive impairment, Journal of Neurolinguistics , vol.61 , p.101025-101025.(SSCI)

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Hsu, Y.-T., Wang, H.-F., Yang, Y.-C., Lien, H.-T., Hua, M.-S. (2021). Boundary extension as a tool for detection of cognitive change among individuals with mild cognitive impairment: A preliminary study, Archives of Gerontology and Geriatrics, vol.94, p.104329-104329.(SCI)

Hsueh, T.-L., Chang, H.-T.* (2021). Effects of semantic coherence and aging on scene construction: A preliminary study, The Journal of Health Sciences , vol.7 , p.26-52.

Chang, H.-T., Chen, T.-F., Cheng,T.-W., Lai, Y.-M., Hua, M.-S. (2018). Arbitrary and semantic forms of associations in subjective memory impairment and amnestic mild cognitive impairment among Taiwanese individuals: A cross-sectional study, Journal of the Formosan Medical Association, vol.117, p.427-433.(SCI)

Chang, H.-T., Chiu, M.-J., Hua, M.-S. (2017). Early detection of semantic memory changes may help predict the course of Alzheimer’s disease, Journal of Alzheimer’s Disease & Parkinsonism , vol.7 , p.3-3.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Cheng,T.-W., Hua, M.-S. (2015). Distinct patterns and clinical implications of semantic memory deterioration among patients with MCI, Alzheimer Disease & Associated Disorders, vol.29, p.124-134.

張馨德 (2012). 淺談行為型額顳葉失智症, 臨床心理通訊, vol.50 , p.5-9.

Lo, H.-W. A., Chen, C.-C., Chou, F. H.-C., Chang, H.-T. (2011). A comparison of posttraumatic stress symptoms in survivors of the Chi-Chi earthquake and Morakot flood, Taiwanese Journal of Psychiatry, vol.25 ,p.167-179.

研討會論文

Chiou, Y.-Y., Chiu, P.-Y., Chang, H.-T. (2025). Cognitive reserve definitions and prediction of cognitive decline in subjective cognitive impairment. 53rd Annual Meeting of the International Neuropsychological Society, New Orleans, LA, USA.

Chang, H.-T., Hua, M.-S., Chen, K.-T., (2024). Similarities in dispersion of cognitive profile Annual Meeting of the International Neuropsychological Society<, New York City, NY, USA.

Huang, Y.-C., Chiu, P.-Y., Liu, C. H., Fan, S.-M., Chang, H.-T.* (2023), Correlation between vascular risk factors and incident dementia among individuals with SCD or MCI in Taiwan, Mid-Year Meeting of the International Neuropsychological Society, Taipei, Taiwan.

Chiu, P.-Y., Chang, H.-T. (2023), Relationship between serum cholesterol levels and cognitive functions among elderly individuals with or without dementia, Mid-Year Meeting of the International Neuropsychological Society, Taipei, Taiwan.

Chiu, P.-Y., Hua, M.-S., Chiu, M.-J., Chen, T.-F., Dong, L.-Y., Cheng, T.-W., Lai-Y.-M., Lien, H.-T., Chang, H.-T. (2022). Performances on MMSE among individuals at neurology clinics across different regions of Taiwan, Annual Meeting of Alzheimer's Disease International, Taipei, Taiwan.

Yu-Zhen Wang, Chia-Hua Lin, Hsing-Tien Lien, Hsin-Fang Wang, Jen-Jen Su, Yu-Wen Cheng, Hsin-Te Chang* (2022), Neuropsychological functions among patients diagnosed with anti-NMDA receptor encephalitis: A case series. 2022 Annual Meeting of the Taiwan Association of Clinical Psychology, Taipei, Taiwan.

Chang, H.-T., Liu, C.-H., Hsu, Y.-T., Yang, Y.-C., Wang, H.-F., Wang, Y.-C., Hua, M.-S. (2021). Obstructive sleep apnea, blood oxygen saturation, and cognitive functions among middle-aged and elderly individuals: A preliminary study in central Taiwan, The Virtual Event of the International Neuropsychological Society

Chang, H.-T., Hua, M.-S. (2020). Evaluation of dual processes in recognition memory using two verbal list learning tests in Taiwan: A preliminary study among young adults. The 1st Virtual Event of the International Neuropsychological Society

Cheng, Y.-H., Chang, H.-T, Cheng, T.-W., Lai, Y.-M., Lien, H.-T., Chiu, M.-J., Chen, T.-F., Hua, M.-S. (2020). Unfamiliar odor recognition ability in subjective memory decline. The 1st Virtual Event of the International Neuropsychological Society

Guo, N.-W., Chang, H.-T., Liu, C.-H., Hsu, Y.-T., Wang, H.-F., Wang, Y.-C., Hua, M.-S. (2019). Blood pressure and cognitive functions among elderly individuals with a low-educational level: A preliminary study in central Taiwan, The 2019 Mid-Year Meeting of International Neuropsychological Society, Rio De Janeiro, Federative Republic of Brazil.

Chang, H.-T., Hua, M.-S. (2019). Qualitative analysis of boundary extension and potential compensatory processes in memory among normal elderly individuals: A preliminary study. The 2019 Annual Meeting of International Neuropsychological Society, New York City, NY, USA.

Chang, H.-T., Hua, M.-S. (2018). Aging facilitates boundary extension. The 2018 Mid-Year Meeting of International Neuropsychological Society, Prague, Czech Republic.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Liu, M.-Y., Fan, W.-C., Cheng,T.-W., Lai, Y.-M., Hua, M.-S. , Patterns and predictive values of deterioration of semantic clustering in amnestic mild cognitive impairment. The 2016 Mid-Year Meeting of International Neuropsychological Society, London, UK

Chang, H.-T., Lin, Y.-C., Lai, Y.-M., Cheng, T.-W., Chen, T.-F., Hua, M.-S. (2016). Content- and context-component memory task performance in elderly individuals with subjective cognitive decline. The 2016 Annual Meeting of International Neuropsychological Society, Boston, MA, USA.

Chiang, M.-S., Chang, H.-T., Lai, Y.-M., Chiu, M.-J., Cheng, T.-W., Chen, T.-F., Hua, M.-S. (2016). "A normative study on the Benton Visual Retention Test in Taiwan sample. The 2016 Annual Meeting of International Neuropsychological Society, Boston, MA, USA.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Lai, Y.-M., Cheng,T.-W., Hua, M.-S. (2015), Potential sensitivity of word list learning task on detection of subjective cognitive decline and amnestic mild cognitive impairment, The 2015 Mid-Year Meeting of International Neuropsychological Society, Sydney, Australia.

Chang, H.-T., Cheng, T.-W., Lin, C,-H., Hua, M.-S. (2014). Neuropsychological features in a patient with suspected multiple system atrophy, The 6th Annual Meeting of Taiwan Association of Clinical Psychology, Taipei, Taiwan.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Cheng,T.-W., Hua, M.-S. (2012). Patterns of semantic memory impairment among patients with mild cognitive impairment: A retrospective study, The 2012 Conference of International Psychogeriatric Association, Cairns, Australia

聯絡方式

Email: changht@cycu.edu.tw

地址：桃園市中壢區中北路200號 科學館711室