Lab Visual

Neuropsychology and Brain Health Lab

About the Lab

This laboratory focuses on interdisciplinary research in cognitive aging, dementia risk factors, and neuropsychological assessment. It integrates clinical and theoretical perspectives, combining approaches from behavioral science, neuropsychology, and public health. The goal is to develop early detection tools and culturally appropriate clinical applications.

Research

Members

Principal investigator: Hsin-Te Chang, Ph.D.

Research assistant: Yu-Hsuan Fan, MSc

Graduate students: Chuan-Fu Yang, Hsin-Hua Chin, Hsiang-Wen Yeh, Hsu-Huei Feng, Hsu-Ming Huang, Chun-Ting Wu, Yi-Peng Lu

Undergraduate project students Tsai-Ni Lei, Tzu-Ling Hsu

Publications

Journal papers

Chiu, P.-Y., Chiu, H.-J., Wei, C.-Y., Tzeng, R.-C., Chang, H.-T., Chen, M.-H. (2026). Dementia with Lewy bodies clinical syndrome (DLBCS) questionnaire: A simple tool for the clinical screening of DLB. Journal of Alzheimer's Disease. (online first)(SCI)

Chen, W.-Y., Chan, D.-C., Chiu, P.-Y., Wang, W.-H., Chen, M.-G., Chang, H.-T.* (2026). Validation and normative data of a modified Autobiographical Interview for use in Taiwanese patients with temporal lobe epilepsy: A preliminary study. Archives of Clinical Neuropsychology. (in progress)(SCI/SSCI)

Li, H.-Y., Lao, I.-H., Chen, Y.-C., Wu, Y.-Y., Chu, Y.-C., Wei, K.C., Chen, P.-Y., Yeh, C.-C., Chen, W.-C., Chang, W.-H., Chang, H.-T., Chen, K.-T. (2026). Impact of subventricular zone invasion on preoperative cognitive decline in diffuse glioma patients. Neurosurgery. vol.98, 921-931.(SCI)

Chiu, P.-Y., Chou, H.-H., Lin, C.-L., Li, H.-H.,Chen, T.-Y., Chen, M.-H., Chang, H.-T.* (2025). Baseline and follow-up change of cholesterol levels predict dementia risk and progression in older adults: A U-shaped relationship. Alzheimer's Research & Therapy. vol.17, 273. (SCIE)

Chang, H.-T., Hua, M.-S., Chiu, M.-J., Chen, T.-F., Lai, Y.-M., Leng, Z.-H., Lin, L.-C. (2025). Optimizing machine learning models for detecting cognitive and subjective cognitive complaint patterns among mild cognitive impairment patients. Chinese Journal of Psychology, vol.67, 77–100.(TSSCI)

Chiu, P.-Y., Yang, C.-C., Mahoor, M. H., Chang, H.-T.* (2024). Cognitive assessment in facilitating early detection of dementia, Frontiers in Dementia, vol.2, 1–2.

Cheng, S.-C., Hua, M.-S., Liao, Y.-C., Chang, H.-T.* (2024). Psychometric properties and norms of the Trail Making Test and the Color Trails Test among elderly individuals in Taiwan: A preliminary study, Chinese Journal of Psychology, vol.66, p.215-245.(TSSCI)

Chang, H.-T., Chan, P.-C, Chiu, P.-Y. (2024). Non-linear relationship between serum cholesterol levels and cognitive change among older people in the preclinical and prodromal stages of dementia: A retrospective longitudinal study in Taiwan, BMC Geriatrics , vol.24 , p.474-474.(SSCI)(SCI)

Lyu, W.-J., Chiu, P.-Y., Liu, C.-H., Liao, Y.-C., Chang, H.-T.* (2024). Determining optimal cutoff scores of Cognitive Abilities Screening Instrument to identify dementia and mild cognitive impairment in Taiwan , BMC Geriatrics, vol.24, p.216-216.(SSCI)(SCI)

Ku, Y.-T., Hua, M.-S., Chiu, P.-Y., Liao, Y.-C., Chang, H.-T.* (2024). Development of a revised version of Subjective Memory Complaints Questionnaire in Taiwan: A preliminary study, Archives of Clinical Neuropsychology, vol.39, p.78-91.(SSCI)(SCI)

Chiu, H.-Y., Chang, H.-T., Chan, P.-C., Chiu, P.-Y. (2023). Cholesterol levels, hormone replacement therapy, and incident dementia among older adult women, Nutrients, vol.15, p.4481-4481.(SCI)

Fan, S.-M, Chiu, P.-Y., Liu, C.-H., Liao, Y.-C., Chang, H.-T.* (2023). Predictive value of hypercholesterolemia, vegetarian diet, and hypertension for incident dementia among elderly Taiwanese individuals with low educational levels, Therapeutic Advances in Chronic Disease , vol.27 , p.20406223231171549-20406223231171549.(SCI)

Li, T.-C., Hua, M.-S., Liu, M.-Y., Liao, Y.-C., Chang, H.-T.* (2023). Extending normative data of the Paced Auditory Serial Addition Test to account for preliminary psychometric properties among elderly individuals in Taiwan, Archives of Clinical Neuropsychology, vol.38, p.264-269.(SSCI)(SCI)

Chang, H.-T., Chiu, P.-Y. (2023). Development of a simple screening tool for determining cognitive status in Alzheimer's disease, PLOS ONE, vol.18 , p.e0280178-e0280178.(SCI)

Huang, Y.-C., Liu, C.-H., Liao, Y.-C., Chang, H.-T.*, Chiu, P.-Y. (2022). Arrhythmia and other modifiable risk factors in incident dementia and MCI among elderly individuals with low educational levels in Taiwan, Frontiers in Aging Neuroscience, vol.14, p.992532-992532.(SCI)

Tzeng, R.-C., Yang, Y.-W., Hsu, K.-C., Chang, H.-T, Chiu, P.-Y. (2022). Sum of boxes of the Clinical Dementia Rating scale highly predict conversion or reversion in predementia stages, Frontiers in Aging Neuroscience , vol.14 , p.1021792-1021792.(SCI)

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Liu, M.-Y., Fan, W.-C., Cheng, T.-W., Lai, Y.-M., Hua, M.-S. (2022). Deterioration and predictive values of semantic networks in mild cognitive impairment, Journal of Neurolinguistics , vol.61 , p.101025-101025.(SSCI)

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Hsu, Y.-T., Wang, H.-F., Yang, Y.-C., Lien, H.-T., Hua, M.-S. (2021). Boundary extension as a tool for detection of cognitive change among individuals with mild cognitive impairment: A preliminary study, Archives of Gerontology and Geriatrics, vol.94, p.104329-104329.(SCI)

Hsueh, T.-L., Chang, H.-T.* (2021). Effects of semantic coherence and aging on scene construction: A preliminary study, The Journal of Health Sciences , vol.7 , p.26-52.

Chang, H.-T., Chen, T.-F., Cheng,T.-W., Lai, Y.-M., Hua, M.-S. (2018). Arbitrary and semantic forms of associations in subjective memory impairment and amnestic mild cognitive impairment among Taiwanese individuals: A cross-sectional study, Journal of the Formosan Medical Association, vol.117, p.427-433.(SCI)

Chang, H.-T., Chiu, M.-J., Hua, M.-S. (2017). Early detection of semantic memory changes may help predict the course of Alzheimer’s disease, Journal of Alzheimer’s Disease & Parkinsonism , vol.7 , p.3-3.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Cheng,T.-W., Hua, M.-S. (2015). Distinct patterns and clinical implications of semantic memory deterioration among patients with MCI, Alzheimer Disease & Associated Disorders, vol.29, p.124-134.

Chang, H. T. (2012). A brief introduction to behaioral variant of frontotemporal dementia, Newsletter of Clinical Psychology, vol.50 , p.5-9.

Lo, H.-W. A., Chen, C.-C., Chou, F. H.-C., Chang, H.-T. (2011). A comparison of posttraumatic stress symptoms in survivors of the Chi-Chi earthquake and Morakot flood, Taiwanese Journal of Psychiatry, vol.25 ,p.167-179.

Conference papers

Chang, H.-T. (2026), Neuropsychological assessment in Taiwan. Asian Conference on Science Education, Extension, and Research, Manila, Republic of the Philippines.

Huang, H.-M.; Fan, Y.-H.; Chen, K.-T.; Chang, H.-T. (2026). Profiles and interrelationships of cognitive domains in glioma patients: A pilot study. Rethinking Intelligence: A NeuroAI Symposium, Taipei, Taiwan.

Chiou, Y.-Y., Chiu, P.-Y., Chang, H.-T. (2025). Cognitive reserve definitions and prediction of cognitive decline in subjective cognitive impairment. 53rd Annual Meeting of the International Neuropsychological Society, New Orleans, LA, USA.

Chang, H.-T., Hua, M.-S., Chen, K.-T. (2024). Similarities in dispersion of cognitive profile. Annual Meeting of the International Neuropsychological Society, New York City, NY, USA.

Huang, Y.-C., Chiu, P.-Y., Liu, C. H., Fan, S.-M., Chang, H.-T.* (2023), Correlation between vascular risk factors and incident dementia among individuals with SCD or MCI in Taiwan, Mid-Year Meeting of the International Neuropsychological Society, Taipei, Taiwan.

Chiu, P.-Y., Chang, H.-T. (2023), Relationship between serum cholesterol levels and cognitive functions among elderly individuals with or without dementia. Mid-Year Meeting of the International Neuropsychological Society, Taipei, Taiwan.

Chiu, P.-Y., Hua, M.-S., Chiu, M.-J., Chen, T.-F., Dong, L.-Y., Cheng, T.-W., Lai-Y.-M., Lien, H.-T., Chang, H.-T. (2022). Performances on MMSE among individuals at neurology clinics across different regions of Taiwan. Annual Meeting of Alzheimer's Disease International, Taipei, Taiwan.

Yu-Zhen Wang, Chia-Hua Lin, Hsing-Tien Lien, Hsin-Fang Wang, Jen-Jen Su, Yu-Wen Cheng, Hsin-Te Chang* (2022), Neuropsychological functions among patients diagnosed with anti-NMDA receptor encephalitis: A case series. 2022 Annual Meeting of the Taiwan Association of Clinical Psychology, Taipei, Taiwan.

Chang, H.-T., Liu, C.-H., Hsu, Y.-T., Yang, Y.-C., Wang, H.-F., Wang, Y.-C., Hua, M.-S. (2021). Obstructive sleep apnea, blood oxygen saturation, and cognitive functions among middle-aged and elderly individuals: A preliminary study in central Taiwan. The Virtual Event of the International Neuropsychological Society

Chang, H.-T., Hua, M.-S. (2020). Evaluation of dual processes in recognition memory using two verbal list learning tests in Taiwan: A preliminary study among young adults. The 1st Virtual Event of the International Neuropsychological Society

Cheng, Y.-H., Chang, H.-T, Cheng, T.-W., Lai, Y.-M., Lien, H.-T., Chiu, M.-J., Chen, T.-F., Hua, M.-S. (2020). Unfamiliar odor recognition ability in subjective memory decline. The 1st Virtual Event of the International Neuropsychological Society

Guo, N.-W., Chang, H.-T., Liu, C.-H., Hsu, Y.-T., Wang, H.-F., Wang, Y.-C., Hua, M.-S. (2019). Blood pressure and cognitive functions among elderly individuals with a low-educational level: A preliminary study in central Taiwan. The 2019 Mid-Year Meeting of International Neuropsychological Society, Rio De Janeiro, Federative Republic of Brazil.

Chang, H.-T., Hua, M.-S. (2019). Qualitative analysis of boundary extension and potential compensatory processes in memory among normal elderly individuals: A preliminary study. The 2019 Annual Meeting of International Neuropsychological Society, New York City, NY, USA.

Chang, H.-T., Hua, M.-S. (2018). Aging facilitates boundary extension. The 2018 Mid-Year Meeting of International Neuropsychological Society, Prague, Czech Republic.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Liu, M.-Y., Fan, W.-C., Cheng,T.-W., Lai, Y.-M., Hua, M.-S. , Patterns and predictive values of deterioration of semantic clustering in amnestic mild cognitive impairment. The 2016 Mid-Year Meeting of International Neuropsychological Society, London, UK

Chang, H.-T., Lin, Y.-C., Lai, Y.-M., Cheng, T.-W., Chen, T.-F., Hua, M.-S. (2016). Content- and context-component memory task performance in elderly individuals with subjective cognitive decline. The 2016 Annual Meeting of International Neuropsychological Society, Boston, MA, USA.

Chiang, M.-S., Chang, H.-T., Lai, Y.-M., Chiu, M.-J., Cheng, T.-W., Chen, T.-F., Hua, M.-S. (2016). "A normative study on the Benton Visual Retention Test in Taiwan sample. The 2016 Annual Meeting of International Neuropsychological Society, Boston, MA, USA.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Lai, Y.-M., Cheng,T.-W., Hua, M.-S. (2015), Potential sensitivity of word list learning task on detection of subjective cognitive decline and amnestic mild cognitive impairment. The 2015 Mid-Year Meeting of International Neuropsychological Society, Sydney, Australia.

Chang, H.-T., Cheng, T.-W., Lin, C,-H., Hua, M.-S. (2014). Neuropsychological features in a patient with suspected multiple system atrophy. The 6th Annual Meeting of Taiwan Association of Clinical Psychology, Taipei, Taiwan.

Chang, H.-T., Chiu, M.-J., Chen, T.-F., Cheng,T.-W., Hua, M.-S. (2012). Patterns of semantic memory impairment among patients with mild cognitive impairment: A retrospective study. The 2012 Conference of International Psychogeriatric Association, Cairns, Australia

Patents

Chang, H.-T.; Chiu, P.-Y. (2026). Screening tools for diagnosing early cognitive disorder (Utility Model)(Taiwan [R.O.C]). 114213040.

Contact

Email: changht@cycu.edu.tw

Address: Rm.711, Science Building, no.200, Zongbei Rd., Zhongli Dist., Taoyuan, Taiwan